Solid Tumor Fusion/Expression Profile

An RNA-Based Assay for Gene Fusions and Expression in Solid Tumors

Solid Tumor Fusion/Expression Profile™ is designed to identify clinically relevant gene fusions and expression changes in solid tumors, supporting tumor classification, biomarker assessment, and molecular interpretation in selected clinical scenarios.

Overview

Solid Tumor Fusion/Expression Profile™

Solid Tumor Fusion/Expression Profile™ is an RNA-based assay focused on the detection of clinically relevant translocations and cancer-associated gene expression changes in solid tumors. The test is designed to identify translocations involving more than 60 genes, including ALK, ROS1, RET, NTRK1, NTRK2, NTRK3, BRAF, CIC, EWSR1, and PD-L1, among others.

It also supports sarcoma screening, diagnosis, and classification through fusion detection and reports expression of clinically relevant genes such as MYC and PD-L1, helping provide additional molecular context in selected cases.

Short Description

Solid Tumor Fusion/Expression Profile™ provides targeted RNA analysis for the evaluation of clinically relevant gene fusions and expression markers in solid tumors. With a turnaround time of 7–10 days, it can support tumor classification, sarcoma workup, and biomarker assessment when fusion and expression-focused information is specifically needed.

Case Studies

Real-world applications of our genomic testing

We provide a selection of real-world case studies that demonstrate the clinical utility and diagnostic impact of our genomic tests. Click the button below to explore individual cases and see how Solid Tumor Profile™ contributes to precision oncology in practice.

Our case study list is continuously updated as new clinical examples become available. We encourage you to revisit this page regularly to explore the latest insights and applications of our genomic testing in real-world settings.

Sample Requirements

FFPE: 1 H&E slide and 6-8 unstained slides, 5-7 microns of tissue fixed with 10% NBF fixative. Please circle tumor for microdissection. Alternatively, the FFPE block can be sent for tumor circling and cutting at our laboratory.

This is a brief overview of the sample requirements for this test. For complete and detailed instructions regarding specimen collection, handling, and submission, please download the full sample guidelines by clicking the button below.

Shipping

Specimen Preparation and Shipping Guidelines

Use the Solid Tumor Transport Kit

Complete the requisition, making sure that all sections are completed in their entirety, including client information, patient Information, specimen information, and test selection.  Missing information may delay reporting of test results.
Diagnosis/patient history is extremely important in rendering the correct interpretation of results and should also be filled out as completely as possible. A copy of a pathology report should be included.
Ensure the specimen is labeled with patient name and number.  A minimum of two patient identifiers is required for each specimen.

For FFPE samples:

If sending FFPE blocks: Insert up to 6 blocks into the plastic block tray provided. Insert block tray into the foam insert in the transport box.
If sending slides: Insert slides into the plastic slide holders provided. Insert the slide holders into the foam insert in the transport box.  The container will hold up to 6 slide holders.
Place folded test requisition(s), and/or manifest(s) if ordered electronically, into the transport box. 
Close the box and tuck the tabs into place. No tape is necessary.

Order Kits

Fill out the form to request kits. Please refer to the Specimen Requirements page for more details.

*GTC will need to set you up in our system if this is your first order.

Solid Tumor Fusion/Expression Profile

An RNA-Based Assay for Gene Fusions and Expression in Solid Tumors